Jung Joo Moon
Jung Joo Moona, Woo Chul Moonb
aCellgenemedix, Newark, NJ, USA; bGood Gene Korea, Seoul, South Korea
Purpose: Genital warts are one of the most common sexually transmitted infections and are known to develop due to human papilloma virus (HPV) infection, especially HPV types 6 and 11. However, their prevalence in male genital warts remains poorly defined. HPV vaccine is administered to both sexes and it is important to investigate their expected impact in male anogenital warts.
Methods: We have herein conducted a multi-center, prospective study to analyze HPV type distribution in genital warts of 1000 Korean men by using DNA microarray that can detect 40 types of genital HPV.
Results: 1000 out of 1015 genital warts showed HPV DNA. Out of 1000 HPV-positive samples, 18.8% showed mixed infections and 81.2% showed single infection.
Of the 18 high-risk (16.2%) and 14 low-risk (94.3%; 12 types) HPV types detected, the most common type of HPV types were HPV6 (59.5%), followed by HPV11 (24.3%), HPV16 (6%), HPV91 (5.3%), and HPV40 (3.3%). 94.3% showed low-risk and 16.2% high-risk, and 10.5% both high- and low-risk type HPV types, respectively. 87.2% showed HPV types (HPV6, 11, 16, 18, 31, 33, 45, 52, and 58) covered by the vaccine. Sixteen of the 200 HPV specimens submitted for sequencing showed discrepant results compared to the DNA sequencing.
Conclusions: Male genital warts predominantly show low-risk type HPV (HPV 6 and 11; 82%). However, high-risk HPV is not uncommon. The Gardasil 9 HPV vaccine is expected to provide protection against about >80% of male genital warts. Further HPV typing studies in male genital warts are necessary.